Chicago born, Brooklyn based, Witz is considered one of the pioneers of the street art movement and has had one of the most sustained careers of any street artist.

In 1983 Witz received a National Endowment of the Arts grant and, in 1992 and 2000 fellowships from the New York Foundation of the Arts were awarded to him.

New York has been a strong source of inspiration for Witz throughout his career and the changing cultural landscape has been the genesis of many of his works. Witz has gained particular attention for his work with stickers and silkscreen posters, particularly the "Holes" series that were pasted around Brooklyn suggesting holes in their respective surfaces.

Another popular media for Witz has been painting using a combination of traditional and digital tools through the creative process. After printing digital images onto canvas Witz then uses the traditional glazing techniques of the Dutch masters to create illusions of depth, form, light and shadow.

Witz's work has been seen in several films including Banksy's 2010, "Exit Through the Gift Shop," Lou Auguste's 2006, "Open Air" documentary and "To Be Seen," the 2005 film by Alice Arnold.

Exhibitions in the Museum of Modern Art in New York and the Indianapolis Museum of Art are complemented by publications of Witz's work in The Wall Street Journal, TIME Magazine, New York Magazine, The Huffington Post, ARTINFO and many more.

In 2010 Gingko Press published a monograph featuring 30 years of artwork, both illegal and otherwise, by Dan Witz.